p53 Antibody
Product Sizes
400ul
£615.00
OAAB16093-400UL
About this Product
- SKU:
- OAAB16093
- Additional Names:
- P53; BCC7; LFS1; BMFS5; TRP53
- Clonality:
- Polyclonal
- Concentration:
- 0.35 mg/ml
- Extra Details:
- Tumor protein p53; a nuclear protein; plays an essential role in the regulation of cell cycle; specifically in the transition from G0 to G1. It is found in very low levels in normal cells; however; in a variety of transformed cell lines; it is expressed in high amounts; and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding; oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion; and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site; and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies; but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
- Host:
- Rabbit
- Immunogen:
- This p53 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T18 of human p53.
- Isotype:
- Ig
- Molecular Weight:
- 44 kDa
- Protein Details:
- Cellular tumor antigen p53
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
