ACSL4 Antibody - middle region
Product Sizes
400ul
£615.00
OAAB15939-400UL
About this Product
- SKU:
- OAAB15939
- Additional Names:
- ACS4; FACL4; LACS4; MRX63; MRX68
- Clonality:
- Polyclonal
- Concentration:
- 2 mg/ml
- Extra Details:
- Long chain acyl-CoA synthetase (LACS); or long chain fatty acid-CoA ligase (FACL); converts free long chain fatty acids into fatty acyl-CoA esters; key intermediates in the synthesis of complex lipids. The FACL4 gene encodes a form of LACS and is expressed in several tissues; including brain. FACL4 cDNA from brain encodes a gene product that shows preference for arachidonic acid as a substrate when expressed in mammalian cells.1 The sequence of the predicted 670-amino acid human protein is 97% identical to that of rat ACS4. FACL4 is highly expressed in adult human brain; especially in the cerebellum and hippocampus; similar to the mouse.2 A strong cytoplasmic staining was found in the Purkinje and granular cells of the cerebellum and the pyramidal layer of hippocampus; indicating that FACL4 is specifically expressed in neurons and not in glial cells. Two patients with Alport syndrome; elliptocytosis; and mental retardation carried a large deletion of the COL4A5 region that included FACL4.3 The absence of FACL4 might play a role in the development of mental retardation or other signs associated with Alport syndrome. Two point mutations; 1 missense and 1 splice site change; were reported in the FACL4 gene in 2 families with nonspecific mental retardation.2 Analysis of enzymatic activity in lymphoblastoid cell lines of affected individuals revealed low levels compared with normal cells; indicating that both mutations are null mutations.
- Host:
- Rabbit
- Immunogen:
- This ACSL4 (FACL4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-267 amino acids from the Central region of human ACSL4 (FACL4).
- Isotype:
- Ig
- Molecular Weight:
- 79 kDa
- Protein Details:
- Long-chain-fatty-acid--CoA ligase 4
- Purification:
- This antibody is purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
