ATG7 Antibody
Product Sizes
400ul
£615.00
OAAB13622-400UL
About this Product
- SKU:
- OAAB13622
- Additional Names:
- GSA7; APG7L; APG7-LIKE
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells; it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure; which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.
- Host:
- Rabbit
- Immunogen:
- This ATG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 494-523 amino acids from human ATG7.
- Isotype:
- Ig
- Molecular Weight:
- 78 kDa
- Protein Details:
- Ubiquitin-like modifier-activating enzyme ATG7
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
