ATG4B Antibody - N-terminal region
Product Sizes
400ul
£615.00
OAAB13556-400UL
About this Product
- SKU:
- OAAB13556
- Additional Names:
- APG4B; AUTL1
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells; it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure; which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy; which cleaves the C-terminal part of either MAP1LC3; GABARAPL2 or GABARAP; allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II; with a revealed C-terminal glycine; is considered to be the phosphatidylethanolamine (PE)-conjugated form; and has the capacity for the binding to autophagosomes.
- Host:
- Rabbit
- Immunogen:
- This ATG4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human ATG4B.
- Isotype:
- Ig
- Molecular Weight:
- 44294 Da
- Protein Details:
- Cysteine protease ATG4B
- Purification:
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
