C4B Antibody - middle region
Product Sizes
400ul
£597.00
OAAB10283-400UL
About this Product
- SKU:
- OAAB10283
- Additional Names:
- C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- This gene encodes the basic form of complement factor 4; part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha; beta; and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin; a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist; such that individuals may have 1; 2; or 3 copies of this gene. In addition; this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
- Host:
- Rabbit
- Immunogen:
- This C4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the Central region of human C4B.
- Isotype:
- Ig
- Molecular Weight:
- 192771 Da
- Protein Details:
- Complement C4-A
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
