CHRNA7 Antibody - N-terminal region
Product Sizes
400ul
£597.00
OAAB10196-400UL
About this Product
- SKU:
- OAAB10196
- Additional Names:
- D-10; CHRNA7; NACHRA7; CHRNA7-DR1
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains; a variable cytoplasmic loop; a fourth conserved transmembrane domain; and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel; displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by; and highly sensitive to; alpha-bungarotoxin. Once this receptor binds acetylcholine; it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Host:
- Rabbit
- Immunogen:
- This CHRNA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human CHRNA7.
- Isotype:
- Ig
- Molecular Weight:
- 56 kDa
- Protein Details:
- Neuronal acetylcholine receptor subunit alpha-7
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
