AXIN2 Antibody - C-terminal region
Product Sizes
400ul
£597.00
OAAB02831-400UL
About this Product
- SKU:
- OAAB02831
- Additional Names:
- AXIL; ODCRCS
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- The Axin-related protein; Axin2; presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway; like its rodent homologs; mouse conductin/rat axil. In mouse; conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon); beta-catenin; glycogen synthase kinase 3-beta; and conductin; which leads to the degradation of beta-catenin. Apparently; the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24; a region that shows frequent loss of heterozygosity in breast cancer; neuroblastoma; and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
- Host:
- Rabbit
- Immunogen:
- This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
- Isotype:
- Ig
- Molecular Weight:
- 93558 Da
- Protein Details:
- Axin-2
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
