ATXN1 Antibody
Product Sizes
400ul
£597.00
OAAB01518-400UL
About this Product
- SKU:
- OAAB01518
- Additional Names:
- ATX1; SCA1; D6S504E
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum; brain stem and spinal cord. Clinically; ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous; with five genetic loci; designated spinocerebellar ataxia (SCA) 1; 2; 3; 4 and 6; being assigned to five different chromosomes. ADCAII; which always presents with retinal degeneration (SCA7); and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5); are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats; producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable; usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
- Host:
- Rabbit
- Immunogen:
- This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
- Isotype:
- Ig
- Molecular Weight:
- 87 kDa
- Protein Details:
- Ataxin-1
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
