DTL Antibody - middle region
Product Sizes
400ul
£597.00
OAAB00993-400UL
About this Product
- SKU:
- OAAB00993
- Additional Names:
- CDT2; RAMP; DCAF2; L2DTL
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control; DNA damage response and translesion DNA synthesis. The DCX(DTL) complex; also named CRL4(CDT2) complex; mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box; and those containing the 'K+4' motif in the PIP box; recruit the DCX(DTL) complex; leading to their degradation. In undamaged proliferating cells; the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA; thereby being involved in PCNA-dependent translesion DNA synthesis.
- Host:
- Rabbit
- Immunogen:
- This DTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL.
- Isotype:
- Rabbit Ig
- Molecular Weight:
- 79468 Da
- Protein Details:
- Denticleless protein homolog
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
