SLC3A2 Antibody - C-terminal region
Product Sizes
400ul
£597.00
OAAB00158-400UL
About this Product
- SKU:
- OAAB00158
- Additional Names:
- 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- Required for the function of light chain amino-acid transporters. Involved in sodium-independent; high-affinity transport of large neutral amino acids such as phenylalanine; tyrosine; leucine; arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger; following an antiport mechanism for amino acid transport; influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1; is also involved in the transport of L-DOPA across the blood-brain barrier; and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D;L-homocysteine complexes; and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8; involved in the cellular activity of small molecular weight nitrosothiols; via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1; regulates the transport activity LAT2 in polarized intestinal cells; by generating and delivering intracellular signals. When associated with SLC7A5; plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
- Host:
- Rabbit
- Immunogen:
- This SLC3A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-615 amino acids from the C-terminal region of human SLC3A2.
- Isotype:
- Rabbit Ig
- Molecular Weight:
- 68 kDa
- Protein Details:
- 4F2 cell-surface antigen heavy chain
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
