BIRC7 antibody - middle region
Product Sizes
25ul
£177.00
AVARP02033-P050-25UL
100 ul
£412.00
AVARP02033-P050-100UL
About this Product
- SKU:
- AVARP02033-P050
- Additional Names:
- KIAP; LIVIN; MLIAP; RNF50; ML-IAP
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin; etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1; and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro; inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases; while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties; with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
- Gene Details:
- Baculoviral IAP repeat containing 7
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human BIRC7
- Molecular Weight:
- 33kDa
- Protein Details:
- Baculoviral IAP repeat-containing protein 7
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
