Anti-PSEN1
Product Sizes
25ul
£177.00
ARP96893-P050-25UL
100 ul
£412.00
ARP96893-P050-100UL
About this Product
- SKU:
- ARP96893-P050
- Additional Names:
- AD3; FAD; PS1; PS-1; S182; ACNINV3
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase; an enzyme that cleaves APP. Also; it is thought that the presenilins are involved in the cleavage of the Notch receptor; such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene; the full-length nature of only some have been determined.
- Gene Details:
- presenilin 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle terminal region of human PSEN1
- Molecular Weight:
- 51 kDa
- Protein Details:
- Presenilin-1
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
