Anti-CASP8
Product Sizes
25ul
£177.00
ARP96836-P050-25UL
100 ul
£412.00
ARP96836-P050-100UL
About this Product
- SKU:
- ARP96836-P050
- Additional Names:
- CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain; a large protease subunit; and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls; which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described; although not all variants have had their full-length sequences determined.
- Gene Details:
- caspase 8
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human CASP8
- Molecular Weight:
- 43 kDa
- Protein Details:
- Caspase-8
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
