Cd247 Antibody Middlel region
Product Sizes
25ul
£177.00
ARP90385-P050-25UL
100 ul
£412.00
ARP90385-P050-100UL
About this Product
- SKU:
- ARP90385-P050
- Additional Names:
- Cd3; T3z; TCR; Cd3h; Cd3z; Tcrk; Tcrz; CD3-et; CD3zet; CD3-zet; Cd3-eta; Cd3zeta; AW552088; Cd3-zeta; A430104F18; 4930549J05Rik; A430104F18Rik
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally; participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
- Gene Details:
- CD247 antigen
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of mouse CD247
- Molecular Weight:
- 18 kDa
- Protein Details:
- CD247 antigen
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
