Atf4 Antibody Middle region
Product Sizes
25ul
£177.00
ARP89000-P050-25UL
100 ul
£412.00
ARP89000-P050-100UL
About this Product
- SKU:
- ARP89000-P050
- Additional Names:
- Atf-; C/AT; CREB; Atf-4; C/ATF; CREB2; CREB-2; TAXREB; TAXREB67
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'); a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP; activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
- Gene Details:
- activating transcription factor 4
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle terminal region of mouse ATF4
- Molecular Weight:
- 38 kDa
- Protein Details:
- cyclic AMP-dependent transcription factor ATF-4
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
