Amfr Antibody-N-terminal region
Product Sizes
25ul
£177.00
ARP88922-P050-25UL
100 ul
£412.00
ARP88922-P050-100UL
About this Product
- SKU:
- ARP88922-P050
- Additional Names:
- gp7; gp78
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D; CYP3A4; CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination; retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
- Gene Details:
- autocrine motility factor receptor
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of mouse AMFR
- Molecular Weight:
- 70 kDa
- Protein Details:
- E3 ubiquitin-protein ligase AMFR
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
