PAX5 Antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP86926-P050-25UL
100 ul
£412.00
ARP86926-P050-100UL
About this Product
- SKU:
- ARP86926-P050
- Additional Names:
- ALL3; BSAP
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel; highly conserved DNA-binding motif; known as the paired box. Paired box transcription factors are important regulators in early development; and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early; but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13; which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype; and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter; suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Gene Details:
- paired box 5
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human PAX5
- Molecular Weight:
- 39 kDa
- Protein Details:
- paired box protein Pax-5
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
