Anti-CDKN1A
Product Sizes
25ul
£177.00
ARP86723-P050-25UL
100 ul
£412.00
ARP86723-P050-100UL
About this Product
- SKU:
- ARP86723-P050
- Additional Names:
- P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes; and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53; through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen; a DNA polymerase accessory factor; and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases; which thus leads to a dramatic activation of cyclin-dependent kinase2; and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
- Gene Details:
- cyclin dependent kinase inhibitor 1A
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human CDKN1A
- Molecular Weight:
- 18 kDa
- Protein Details:
- Cyclin-dependent kinase inhibitor 1
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
