BRSK2 Antibody - middle region
Product Sizes
25ul
£177.00
ARP85189-P050-25UL
100 ul
£412.00
ARP85189-P050-100UL
About this Product
- SKU:
- ARP85189-P050
- Additional Names:
- SAD1; SADA; STK29; PEN11B; C11orf7
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis; cell cycle progress and insulin secretion. Phosphorylates CDK16; CDC25C; MAPT/TAU; PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1; acts as a key regulator of polarization of cortical neurons; probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons; leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels; probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion; BRSK2 phosphorylated at Thr-260 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
- Gene Details:
- BR serine/threonine kinase 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human BRSK2
- Molecular Weight:
- 67 kDa
- Protein Details:
- serine/threonine-protein kinase BRSK2
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
