APPL2 Antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP82058-P050-25UL
100 ul
£412.00
ARP82058-P050-100UL
About this Product
- SKU:
- ARP82058-P050
- Additional Names:
- DIP13B
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5; which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain; a central pleckstrin homology (PH) domain; and a C-terminal phosphotyrosine binding (PTB) domain; and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome; also known as Phelan-McDermid syndrome.
- Gene Details:
- adaptor protein; phosphotyrosine interaction; PH domain and leucine zipper containing 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human APPL2
- Molecular Weight:
- 73 kDa
- Protein Details:
- DCC-interacting protein 13-beta
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
