BRCC3 Antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP81799-P050-25UL
100 ul
£412.00
ARP81799-P050-100UL
About this Product
- SKU:
- ARP81799-P050
- Additional Names:
- C6.1A; BRCC36; CXorf53
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC); which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response; where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains; and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya; a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
- Gene Details:
- BRCA1/BRCA2-containing complex subunit 3
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human BRCC3
- Molecular Weight:
- 34 kDa
- Protein Details:
- lys-63-specific deubiquitinase BRCC36
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
