PPP1R12A Antibody - middle region
Product Sizes
25ul
£177.00
ARP80931-P050-25UL
100 ul
£412.00
ARP80931-P050-100UL
About this Product
- SKU:
- ARP80931-P050
- Additional Names:
- MBS; GUBS; M130; MYPT1
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Myosin phosphatase target subunit 1; which is also called the myosin-binding subunit of myosin phosphatase; is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation; which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound; active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase; which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase); which is activated by GTP. RhoA; phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus; Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.
- Gene Details:
- protein phosphatase 1 regulatory subunit 12A
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human PPP1R12A
- Molecular Weight:
- 113 kDa
- Protein Details:
- protein phosphatase 1 regulatory subunit 12A
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
