Anti-KIR2DL2
Product Sizes
25ul
£177.00
ARP80369-P050-25UL
100 ul
£412.00
ARP80369-P050-100UL
About this Product
- SKU:
- ARP80369-P050
- Additional Names:
- NKAT6; p58.2; CD158b; NKAT-6; CD158B1
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes; although several "framework" genes are found in all haplotypes (KIR3DL3; KIR3DP1; KIR3DL4; KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM); while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus; KIR proteins are thought to play an important role in regulation of the immune response.
- Gene Details:
- killer cell immunoglobulin like receptor; two Ig domains and long cytoplasmic tail 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human KIR2DL2
- Molecular Weight:
- 38 kDa
- Protein Details:
- killer cell immunoglobulin-like receptor 2DL2
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
