IKZF1 Antibody - middle region
Product Sizes
25ul
£177.00
ARP74585-P050-25UL
100 ul
£412.00
ARP74585-P050-100UL
About this Product
- SKU:
- ARP74585-P050
- Additional Names:
- IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system; and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain; which contains two zinc finger motifs that are required for hetero- or homo-dimerization; and for interactions with other proteins. The isoforms; however; differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence; resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm; and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies; such as acute lymphoblastic leukemia (ALL).
- Gene Details:
- IKAROS family zinc finger 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human IKZF1
- Molecular Weight:
- 42 kDa
- Protein Details:
- DNA-binding protein Ikaros
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
