ERCC8 Antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP74518-P050-25UL
100 ul
£412.00
ARP74518-P050-100UL
About this Product
- SKU:
- ARP74518-P050
- Additional Names:
- CSA; CKN1; UVSS2
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- ERCC8 is a substrate-recognition component of the CSA complex; a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex; involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2; HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human ERCC8
- Molecular Weight:
- 43kDa
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
