ASAP2 Antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP67972-P050-25UL
100 ul
£412.00
ARP67972-P050-100UL
About this Product
- SKU:
- ARP67972-P050
- Additional Names:
- PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif; followed by a pleckstrin homology (PH) domain; an Arf-GAP domain; an ankyrin homology region; a proline-rich region; and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane; where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro; and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition; it functions as a substrate and downstream target for PYK2 and SRC; a pathway that may be involved in the regulation of vesicular transport.
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human ASAP2
- Molecular Weight:
- 112kDa
- Protein Details:
- Arf-GAP with SH3 domain; ANK repeat and PH domain-containing protein 2
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
