AP2A2 antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP59974-P050-25UL
100 ul
£412.00
ARP59974-P050-100UL
About this Product
- SKU:
- ARP59974-P050
- Additional Names:
- HIP9; HYPJ; ADTAB; HIP-9; CLAPA2
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles; CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated; non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids; positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
- Gene Details:
- Adaptor-related protein complex 2; alpha 2 subunit
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human AP2A2
- Molecular Weight:
- 104kDa
- Protein Details:
- AP-2 complex subunit alpha-2
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
