CD22 antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP59863-P050-25UL
100 ul
£412.00
ARP59863-P050-100UL
About this Product
- SKU:
- ARP59863-P050
- Additional Names:
- SIGLEC2; SIGLEC-2
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins; one of which is CD45. CD22 preferentially binds to alpha-2;6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
- Gene Details:
- CD22 molecule
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human CD22
- Molecular Weight:
- 95kDa
- Protein Details:
- B-cell receptor CD22
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
