C11orf73 antibody - middle region
Product Sizes
25ul
£177.00
ARP56903-P050-25UL
100 ul
£412.00
ARP56903-P050-100UL
About this Product
- SKU:
- ARP56903-P050
- Additional Names:
- HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s; indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.
- Gene Details:
- Hikeshi; heat shock protein nuclear import factor
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human C11orf73
- Molecular Weight:
- 21kDa
- Protein Details:
- protein Hikeshi
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
