Apbb1 antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP55471-P050-25UL
100 ul
£412.00
ARP55471-P050-100UL
About this Product
- SKU:
- ARP55471-P050
- Additional Names:
- Rir; Fe65
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs); recruiting other pro-apoptosis factors such as MAPK8/JNK1. Apbb1 is required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60; probably explains its trancription activation activity.Apbb1 functions in association with TSHZ3; SET and HDAC factors as a transcriptional repressor; that inhibits the expression of CASP4. Apbb1 is associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
- Gene Details:
- Amyloid beta (A4) precursor protein-binding; family B; member 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Molecular Weight:
- 78kDa
- Protein Details:
- Amyloid beta A4 precursor protein-binding family B member 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
