GUCA1A antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP54309-P050-25UL
100 ul
£412.00
ARP54309-P050-100UL
About this Product
- SKU:
- ARP54309-P050
- Additional Names:
- COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase; the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and; presumably; increased cell death. This gene is expressed in retina and spermatagonia.
- Gene Details:
- Guanylate cyclase activator 1A (retina)
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
- Molecular Weight:
- 23kDa
- Protein Details:
- Guanylyl cyclase-activating protein 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
