8ODP Antibody - middle region
Product Sizes
25ul
£177.00
ARP49190-P050-25UL
100 ul
£412.00
ARP49190-P050-100UL
About this Product
- SKU:
- ARP49190-P050
- Additional Names:
- MTH1
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates; such as 8-oxo-dGTP; 8-oxo-dATP; 2-hydroxy-dATP; and 2-hydroxy rATP; to monophosphates; thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm; with some in the mitochondria; suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants; some of which encode distinct isoforms; have been identified. Additional variants have been observed; but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional; longer isoform (p26) has been described.
- Gene Details:
- nudix hydrolase 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of Human 8ODP
- Molecular Weight:
- 21kDa
- Protein Details:
- 7;8-dihydro-8-oxoguanine triphosphatase
- Purification:
- Affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
