GNAS antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP42693-P050-25UL
100 ul
£412.00
ARP42693-P050-100UL
About this Product
- SKU:
- ARP42693-P050
- Additional Names:
- AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; C20orf45
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Mutations in GNAS gene result in pseudohypoparathyroidism type 1a; pseudohypoparathyroidism type 1b; Albright hereditary osteodystrophy; pseudopseudohypoparathyroidism; McCune-Albright syndrome; progressive osseus heteroplasia; polyostotic fibrous dysplasia of bone; and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally; paternally; and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons; and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists; and this antisense transcript and one of the transcripts are paternally expressed; produce noncoding RNAs; and may regulate imprinting in this region. In addition; one of the transcripts contains a second overlapping ORF; which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed; which results in different forms of the stimulatory G-protein alpha subunit; a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene; but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a; pseudohypoparathyroidism type 1b; Albright hereditary osteodystrophy; pseudopseudohypoparathyroidism; McCune-Albright syndrome; progressive osseus heteroplasia; polyostotic fibrous dysplasia of bone; and some pituitary tumors.
- Gene Details:
- GNAS complex locus
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human GNAS
- Molecular Weight:
- 46 kDa
- Protein Details:
- Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
