VPREB1 antibody - middle region
Product Sizes
25ul
£177.00
ARP42346-P050-25UL
100 ul
£412.00
ARP42346-P050-100UL
About this Product
- SKU:
- ARP42346-P050
- Additional Names:
- IGI; IGVPB; VPREB; CD179a
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- VPREB1 belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development; namely; in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation.CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development; namely; in proB and early preB cells. CD179a has an Ig V domain-like structure; but lacks the last beta-strand (beta7) of a typical V domain. Instead; it has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure; which is called the surrogate light chain or pseudo light chain. In this complex; the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells; CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure; so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet; the deficiency of other components of preB cell receptor such as CD179b; Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation; differentiation from the proB cell to preB cell stage; 2) allelic exclusion at the Ig heavy chain gene locus; and 3) promotion of Ig light chain gene rearrangements. Thus; preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Gene Details:
- Pre-B lymphocyte 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human VPREB1
- Molecular Weight:
- 16kDa
- Protein Details:
- Immunoglobulin iota chain
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
