Btrc antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP42160-P050-25UL
100 ul
£412.00
ARP42160-P050-100UL
About this Product
- SKU:
- ARP42160-P050
- Additional Names:
- Sl; HOS; FWD1; Fbw1; Fbw1a; Slimb; b-TrCP; beta-T; Beta-Tr; beta-TrCP; Beta-Trcp1; SCF b-TRCP; E3RSIkappaB; E3RS-IkappaB
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA; NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit; ATF4; SMAD3; SMAD4; CDC25A; DLG1; FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
- Gene Details:
- Beta-transducin repeat containing protein
- Host:
- Rabbit
- Molecular Weight:
- 69kDa
- Protein Details:
- F-box/WD repeat-containing protein 1A
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
