ACTN2 antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP41463-T100-25UL
100 ul
£373.00
ARP41463-T100-100UL
About this Product
- SKU:
- ARP41463-T100
- Additional Names:
- MPD6; CMH23; CMD1AA; MYOCOZ
- Clonality:
- Polyclonal
- Concentration:
- 1.0 mg/ml
- Extra Details:
- The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans; ACTN2 is expressed in all muscle fibres; while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed; spatially and temporally; during embryonic development and; in contrast to humans; alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle; suggesting independent function.Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins; including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells; the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions; where it is involved in binding actin to the membrane. In contrast; skeletal; cardiac; and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies; where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific; alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Transcript variants resulting from the use of multiple poly_A sites have been observed.
- Gene Details:
- Actinin; alpha 2
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human ACTN2
- Molecular Weight:
- 98kDa
- Protein Details:
- Alpha-actinin-2
- Purification:
- Protein A purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
