AUH antibody - C-terminal region
Product Sizes
25ul
£177.00
ARP40374-P050-25UL
100 ul
£412.00
ARP40374-P050-100UL
About this Product
- SKU:
- ARP40374-P050
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE); a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos; c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase; an enzyme involved in fatty acid degradation; and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb; and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE); a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos; c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase; an enzyme involved in fatty acid degradation; and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb; and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form.
- Gene Details:
- AU RNA binding protein/enoyl-CoA hydratase
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the C terminal region of human AUH
- Molecular Weight:
- 37kDa
- Protein Details:
- Methylglutaconyl-CoA hydratase; mitochondrial
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
