ACCN2 antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP35298-P050-25UL
100 ul
£412.00
ARP35298-P050-100UL
About this Product
- SKU:
- ARP35298-P050
- Additional Names:
- ASIC; ACCN2; BNaC2
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- ACCN2 is the cation channel with high affinity for sodium; which is gated by extracellular protons and inhibited by the diuretic amiloride. ACCN2 is also permeable for Ca2+; Li+ and K+. ACCN2 generates a biphasic current with a fast inactivating and a slow sustained phase. ACCN2 mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. ACCN2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini; 2 hydrophobic transmembrane regions; and a large extracellular loop; which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons; and it may be an ion channel subunit; however; its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.
- Gene Details:
- Acid-sensing (proton-gated) ion channel 1
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human ACCN2
- Molecular Weight:
- 65kDa
- Protein Details:
- Acid-sensing ion channel 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
