Accn2 antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP35035-P050-25UL
100 ul
£412.00
ARP35035-P050-100UL
About this Product
- SKU:
- ARP35035-P050
- Additional Names:
- A; AS; Acc; BNa; ASIC; Accn2; BNaC2; ASIC1a; AI843610; B530003N02Rik
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Accn2 is a cation channel with high affinity for sodium; which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+; Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.
- Gene Details:
- Amiloride-sensitive cation channel 2; neuronal
- Host:
- Rabbit
- Molecular Weight:
- 60kDa
- Protein Details:
- Acid-sensing ion channel 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
