AR antibody - N-terminal region
Product Sizes
25ul
£177.00
ARP30974-P050-25UL
100 ul
£412.00
ARP30974-P050-100UL
About this Product
- SKU:
- ARP30974-P050
- Additional Names:
- KD; AIS; AR8; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- AR has 3 major functional domains: the N-terminal domain; DNA-binding domain; and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand; the receptor dissociates from accessory proteins; translocates into the nucleus; dimerizes; and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS).The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain; DNA-binding domain; and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand; the receptor dissociates from accessory proteins; translocates into the nucleus; dimerizes; and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
- Gene Details:
- Androgen receptor
- Host:
- Rabbit
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N terminal region of human AR
- Molecular Weight:
- 99kDa
- Protein Details:
- Androgen receptor
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
