WISP1 Blocking peptide
Product Sizes
100ug
£183.00
AAP97460-100UG
About this Product
- SKU:
- AAP97460
- Additional Names:
- WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1
- Extra Details:
- This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily; which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich; glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain; von Willebrand factor type C module; thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells; and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan; two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue; and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
- Gene Details:
- WNT1 inducible signaling pathway protein 1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
