PSEN1 Blocking peptide
Product Sizes
100ug
£183.00
AAP96893-100UG
About this Product
- SKU:
- AAP96893
- Additional Names:
- AD3; FAD; PS1; PS-1; S182; ACNINV3
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase; an enzyme that cleaves APP. Also; it is thought that the presenilins are involved in the cleavage of the Notch receptor; such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene; the full-length nature of only some have been determined.
- Gene Details:
- presenilin 1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
