MRVI1 Blocking peptide
Product Sizes
100ug
£183.00
AAP88721-100UG
About this Product
- SKU:
- AAP88721
- Additional Names:
- IRAG; JAW1L; MRVI1
- Extra Details:
- This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein; which is found in the membrane of the endoplasmic reticulum; is similar to Jaw1; a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation; and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene; and alternative translation start sites; including a non-AUG (CUG) start site; are used.
- Gene Details:
- murine retrovirus integration site 1 homolog
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
