PAN3 Blocking peptide
Product Sizes
100ug
£183.00
AAP79409-100UG
About this Product
- SKU:
- AAP79409
- Extra Details:
- Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex; one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms; namely exosome-mediated 3'-5' exonucleolytic degradation; or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity; recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP; and to miRNA targets via its interaction with GW182 family proteins.
- Gene Details:
- PAN3 poly(A) specific ribonuclease subunit
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
