IFIT3 Blocking Peptide
Product Sizes
100ug
£183.00
AAP76288-100UG
About this Product
- SKU:
- AAP76288
- Additional Names:
- P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49
- Extra Details:
- IFIT3 is a IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes; cell migration; proliferation; signaling; and viral replication. It enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. It exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally; CDKN1B/p27 turnover is regulated by COPS5; which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin- dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm; thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC; a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
