DMP1 Blocking Peptide
Product Sizes
100ug
£183.00
AAP74929-100UG
About this Product
- SKU:
- AAP74929
- Additional Names:
- ARHP; ARHR; DMP-1
- Extra Details:
- Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein; which is critical for proper mineralization of bone and dentin; is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains; multiple phosphorylation sites; a functional arg-gly-asp cell attachment sequence; and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix; where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia; a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
