CHRFAM7A
Product Sizes
100ug
£183.00
AAP35408-100UG
About this Product
- SKU:
- AAP35408
- Additional Names:
- D-10; CHRNA7; NACHRA7; CHRNA7-DR1
- Extra Details:
- The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7; which is located on chromosome 15 in a region associated with several neuropsychiatric disorders; is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed; and two variants exist; for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene; translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
- Gene Details:
- CHRNA7 (cholinergic receptor; nicotinic; alpha 7; exons 5-10) and FAM7A (family with sequence similarity 7A; exons A-E) fusion
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage; store at -20C. Avoid repeat freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules
