Rheumatoid Factor, Immunoglobulin M (RF - IgM)
Product Sizes
2500 IU
£285.00
16-16-1806030-2500IU
250 ul
£475.00
16-16-1806030-250UL
10000 IU
£1005.00
16-16-1806030-10000IU
1 ml
£1605.00
16-16-1806030-1ML
25000 IU
£1750.00
16-16-1806030-25000IU
100000 IU
£4750.00
16-16-1806030-100000IU
About this Product
- SKU:
- 16-16-1806030
- Additional Names:
- In Vitro Diagnostics, Autoimmune Disease, Rheumatoid Arthritis|RF-IgM
- Buffer:
- Liquid in 20 mM Sodium Phosphate, pH 7.4, with 150 mM NaCl and 0.09% NaN3
- CE/IVD:
- RUO
- Extra Details:
- Rheumatoid factor IgM (RF-IgM) is an autoantibody produced by the immune system that targets the Fc region of immunoglobulin G (IgG), forming immune complexes that can drive inflammation. RF-IgM is the most clinically significant and commonly measured isotype among rheumatoid factors, present in approximately 70-80% of patients with rheumatoid arthritis (RA). Functionally, RF-IgM amplifies inflammatory responses by increasing the recruitment of IgG into immune complexes, which then stimulate macrophages to secrete proinflammatory cytokines such as TNF-A Alpha, IL-6, and IL-8, and enhance complement activation, contributing to joint inflammation and tissue damage in RA. High levels of RF-IgM are associated with more severe, progressive disease, greater joint destruction, and increased risk of extra-articular manifestations. Beyond RA, RF-IgM can be elevated in other autoimmune diseases (e.g., Sjoegren's syndrome, systemic lupus erythematosus) and chronic infections (e.g., hepatitis C, endocarditis)2. Clinically, RF-IgM serves as a diagnostic and prognostic marker in RA and is used alongside anti-cyclic citrullinated peptide (anti-CCP) antibodies to improve diagnostic accuracy and guide disease management.
- Formulation:
- Liquid in 20 mM Sodium Phosphate, pH 7.4, with 150 mM NaCl and 0.09% NaN3
- Molecular Weight:
- 970,000 Da
- Physical State:
- Liquid
- Purity:
- Elevation Level: 1000 to 2000 U/ml
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Bioscience, Inc.
- Type:
- Antibody
