Secretory IgA (sIgA)
Product Sizes
1 mg
16-13-090701-1MG
5 mg
16-13-090701-5MG
10 mg
16-13-090701-10MG
About this Product
- SKU:
- 16-13-090701
- Additional Names:
- Infection, In Vitro Diagnostics, Autoimmune Diseases|SIgA
- Buffer:
- Lyophilized from 20 mM phosphate, pH 7.4, with 150 mM NaCl.
- CE/IVD:
- RUO
- Extra Details:
- Secretory Immunoglobulin A (SIgA) is the predominant antibody found on mucosal surfaces, including the gastrointestinal, respiratory, and genitourinary tracts, as well as in secretions such as saliva, tears, and colostrum. Structurally, SIgA is a polypeptide complex composed of two IgA monomers, a joining (J) chain, and a secretory component, which protects it from enzymatic degradation and enables it to function in harsh environments like the gut. SIgA serves as the first line of immune defense by binding to pathogens and toxins, preventing their attachment and invasion of epithelial cells, a process known as immune exclusion. It also helps maintain mucosal barrier integrity and regulates the composition of the microbiota by interacting with commensal bacteria. Functionally, SIgA neutralizes viruses, bacteria, and other antigens without triggering strong inflammatory responses, thereby promoting immune tolerance and mucosal homeostasis. Clinically, altered SIgA levels are associated with increased susceptibility to infections, autoimmune diseases, and inflammatory conditions of the mucosa, making it a valuable marker for mucosal immune status and gut health.
- Formulation:
- Lyophilized from 20 mM phosphate, pH 7.4, with 150 mM NaCl.
- Molecular Weight:
- 385,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from human colostrum shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
