oYo-Link[R] DM1 Antibody Labeling Reagent
Product Sizes
100 ug
£492.00
AT7002-100UG
5 x 100 ug
£1,455.00
AT7002-5X100UG
10 x 100 ug
£2,123.00
AT7002-10X100UG
About this Product
- SKU:
- AT7002
- Application:
- Cell-based/Functional Assay
- Buffer:
- PBS
- Concentration:
- 270 ug/ml
- Extra Details:
- Research Use Only Application: Antibody conjugation Reagent for Targeted cell death; Targeted cell death for cancer cells; High-throughput screening with cell killing assays oYo-Link[R] DM1 is an Antibody-Drug Conjugation Reagent allowing for site-specific labeling of DM1 drug labels to the heavy-chains of compatible antibodies with up to two labels per antibody. oYo-Link[R] limits the attachment of the DBCO drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DBCO drugs to be attached per antibody, providing precise antibody-drug conjugate ratios. As a synthetic derivative of the microtubule-targeted agent mertansine, also known as the maytansinoid DM1, the DM1 ADC is an antibody-conjugatable, anti-mitotic agent that overcomes systemic toxicity associated with mertansine and enhances tumor-specific delivery. The antibody labeling procedure simply requires mixing oYo-Link[R] DM1 with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Catalog # AT7002 Requirements: To label your compatible antibodies with oYo-Link[R], you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from our list or purchase AlphaThera's LED Photo-Crosslinking Device. Technical Support: For science questions or questions concerning compatibility email support@alphathera.com
- Molecular Weight:
- 8 kDa
- Physical State:
- Dried pellet
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 2-8[o]C
- Supplier:
- AlphaThera
- Type:
- Buffers & General Consumables: Others